Effects of High-Intensity Interval Training (HIIT) on Functional Performance Compared to Moderate-Intensity Continuous Training (MICT) in Cancer Patients

Effects of High-Intensity Interval Training (HIIT) on Functional Performance Compared to Moderate-Intensity Continuous Training (MICT) in Cancer Patients

Type of Study: Systematic Review & Meta-analysis

Publication: October 2023, DOI: 10.1007/s00520-023-08103-9

Authors: T. Neuendorf, R. Haase, S. Schroeder, M. Schumann, N. Nitzsche

🔍What was observed?

This meta-analysis examined how well high-intensity interval training (HIIT) works for cancer patients compared to moderate-intensity continuous training (MICT). The focus was particularly on:

  • Functional performance

  • Maximum oxygen uptake (VO₂ max)

📊 A total of 31 studies with 1,555 patients were evaluated, including 8 studies with 268 patients for the detailed meta-analysis on VO₂ max.

➡️ Result: HIIT improves both physical performance and oxygen uptake—sometimes better than MICT.

✨ Highlights & Annotations

“HIIT improves the VO₂ max in cancer patients by an average of 10.68%, MICT by 7.4%.”
→ HIIT showed a significantly higher training effect (p = 0.009).

✅ 6-Minute Walk Test: +8.63 m
✅ Sit-and-Reach Mobility: +2.7 cm
✅ Training effects moderately correlate with training volume (ρ = 0.49)

📌 Good to know

HIIT could help cancer patients regain reduced performance due to illness or therapy.


  • Training programs should be individualized—the effectiveness significantly depends on intensity, duration, and frequency.

  • Studies show that shorter, intense training stimuli with breaks often work better than longer moderate exertion.

"Future studies should incorporate functional parameters more extensively to enable a better comparison between HIIT and MICT."

📈 Conclusion

This work provides important fundamentals for the integration of HIIT into prevention, therapy, and aftercare for oncology patients. The results clearly advocate the use of HIIT—as part of a modern rehabilitation program—under professional supervision.

What was observed?

Highlights & Annotations

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