Study Type: Randomized, controlled double-blind study
Location: Israel, Sagol Center for Hyperbaric Medicine and Research
Participants: 73 patients with Long-COVID
Publication: Scientific Reports, Nature Portfolio
🔍What was observed?
This groundbreaking study demonstrates that Hyperbaric Oxygen Therapy (HBOT) can significantly help alleviate neurocognitive symptoms following a COVID illness. These include:
Concentration difficulties
Memory issues
Fatigue
Depression and anxiety
📊 The study participants received 40 HBOT sessions over 2 months. Compared to a placebo group, they showed significant improvements in:
Attention
Working Memory
Processing Speed
Mental Well-being
✨ Highlights & Anmerkungen
"HBOT demonstrated a significant improvement in neurocognitive functions, objectively measurable through fMRI and cognitive tests."
✅ Randomized placebo control group
✅ fMRI-supported brain function imaging
✅ Improvements in mental health (anxiety, depression)
✅ Long-lasting effects after the end of therapy
📌 Good to know
The study showed that HBOT can cause changes in brain regions such as the prefrontal cortex and the hippocampus—areas associated with memory, motivation, and mood.
Participants, on average, still experienced symptoms 6 months after COVID—indicating it was not an early phase.
The treatment had minimal side effects and was well-tolerated.
"HBOT could be an effective therapeutic approach for treating long-term cognitive and psychological symptoms in long-COVID patients."
📈 Conclusion
The study provides the clearest evidence to date that HBOT not only improves oxygen supply - but can also initiate profound regenerative processes in the brain. This makes it one of the most promising options in the treatment of long-COVID and 'Brain Fog'.
Study (PDF)
Study (PDF)
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