The Effect of Hyperbaric Oxygen Therapy on the Pathophysiology of Skin Aging – A Prospective Clinical Study

The Effect of Hyperbaric Oxygen Therapy on the Pathophysiology of Skin Aging – A Prospective Clinical Study

Authors: Hachmo et al., Israel
Publication: Aging (Albany NY), Peer-reviewed Journal
Type of Study: Prospective, controlled clinical study
Participants: 70 healthy adults over the age of 64
Treatment Protocol: 60 HBOT sessions over 3 months

🔍What was observed?

This study shows that HBOT in healthy older individuals:


  • Increases capillary density in the skin 🩸

  • Enhances fibroblast activity (Collagen production!)

  • Reduces wrinkles and improves elasticity

  • Extends telomeres and reduces senescent cells (visible in skin samples)

📊 The measurement was conducted using skin biopsies, histological examinations, imaging, and tissue analyses.

✨ Highlights & Annotations

"HBOT led to a significant increase in dermal vascularization as well as morphologic skin rejuvenation effects."

✅ Increased collagen fibers (Type I & III)
✅ Enhanced cell division in the dermis
✅ Reduction of senescent cells (p16 and p21 positive)
✅ Improvement in skin thickness & structure
✅ No side effects reported

📌 Good to know

  • The effects were not merely cosmetic, but histologically and molecularly verifiable

  • HBOT was shown to be a non-invasive, biological 'anti-aging therapy' that directly impacts tissue renewal

  • Particularly relevant for dermatological anti-aging concepts, prevention, and aesthetic medicine

"HBOT works through physiological stimuli and can effectively reverse the aging process at the skin level – far beyond cosmetic approaches."

📈 Conclusion

This study provides the scientifically proven evidence that HBOT generates genuine, measurable skin rejuvenation at the cellular level. Thus, it becomes a pioneering option in preventive and regenerative medicine – for skin, tissue & systemic vitality.

What was observed?

Highlights & Callouts

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