Publication: Federal Health Gazette 2022
Authors: Prof. Dr. Jens Enno Wilkens, Prof. Dr. Horst Christian Vollmar
Type of Study: Scientific review article with cell biological analysis
πWhat was observed?
This study demonstrates at the cellular level how HBOT:
improves the function of mitochondria (the energy powerhouses of the cell)
reduces oxidative stress, which is considered a central factor in cellular aging
activates cellular signaling pathways that initiate repair processes
π¬ The focus is on chronic inflammatory and degenerative diseases such as Long COVID, ME/CFS, neurodegenerative diseases, but also healthy individuals experiencing a decline in performance.
β¨ Highlights & Callouts
"HBOT leads to the reprogramming of mitochondrial metabolic pathways with a shift towards more efficient energy production."
β
Activation of antioxidant enzymes (e.g., SOD, catalase, glutathione peroxidase)
β
Inhibition of pro-inflammatory signaling pathways (e.g., NF-ΞΊB)
β
Induction of mitochondrial biogenesis through PGC-1Ξ±
β
Improvement of ATP balance β more cellular energy
π Good to know
Mitochondria respond sensitively to extreme oxygen levels β the switch between oversupply and relative hypoxia triggers cellular adaptation mechanisms
The study also explains the concept of mitochondrial resilience: Cells learn under HBOT to cope better with stress
The authors compare HBOT to cellular interval training
"Hyperbaric oxygen therapy does not primarily act through the administration of oxygen, but rather by stimulating adaptive cellular processes that typically occur only under extreme conditions."
π Conclusion
This work explains in detail why HBOT functions at the cellular level β from energy production to long-term cellular health. It is excellent for demonstrating the scientific depth of the therapy without being reduced to mere symptom relief.
Study (PDF)
Study (PDF)
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