Study Location: Israel, Sagol Center for Hyperbaric Medicine and Research
Publication: Aging (Albany NY), Peer-reviewed Journal
Study Design: Combination of animal study (mouse model) & clinical pilot study with older patients
🔍What was observed?
This study examines the biological effects of HBOT on Alzheimer's disease, both in a mouse model and in older individuals with cognitive decline.
🧪 In both groups, it was shown that HBOT:
Reduces amyloid-β deposits (a central marker in Alzheimer's)
Decreases vascular dysfunction
Improves cognitive performance (in humans)
➡️ The therapy promotes neuronal plasticity, enhances cerebral blood flow, and reduces oxidative damage.
✨ Highlights & Callouts
“HBOT significantly reduced the amyloid burden in the hippocampus and cortex.”
→ Particularly relevant brain areas for memory and orientation.
✅ Improved cerebral blood circulation
✅ Reduction of inflammatory markers
✅ Increase in brain oxygen saturation
✅ Mouse model: significant improvement in behavior tests
✅ Human subjects: cognitive tests showed improvements after 60 sessions
📌 Good to know
The pilot study in humans included older participants with objectively measurable cognitive decline, but still no manifest dementia.
The HBOT treatment consisted of 60 sessions over 3 months at 2 ATA.
The study suggests using HBOT in the future as an early intervention for Alzheimer's risk - thus preventively or in early stages.
Our findings suggest that HBOT can be an effective therapeutic tool against vascular and amyloid-related Alzheimer's pathologies in both a mouse model and humans with cognitive decline.
📈 Conclusion
The study provides scientific evidence that Hyperbaric Oxygen Therapy can not only alleviate symptoms but also slow down pathological Alzheimer processes. In particular, the combination of improved circulation and reduction of neurotoxic deposits makes HBOT a promising approach for future dementia therapies.
Study (PDF)
Study (PDF)
Legal Notice Terms and Conditions About Us
X4 Innovation GmbH © 2025 All Rights Reserved
