Hyperbaric Oxygen Therapy – From Mechanisms to Cognitive Enhancement

Authors: J.E. Wilkens et al.
Type: Scientific Review Article
Publication: Bundesgesundheitsblatt, 2023
Focus: Mechanisms of HBOT and its clinical application to enhance cognition and brain function

🔍What was observed?

This study provides a detailed analysis of how HBOT affects the human body – and explains why it shows particular potential in neurological disorders and cognitive decline.

🔬 Both molecular mechanisms and clinical trial results are discussed. Particularly exciting:

HBOT activates regenerative processes in the brain
Promotes neuroplasticity, i.e., the formation of new neuronal connections
Improves cerebral blood flow
Inhibits inflammatory processes and oxidative stress
Stimulates stem cell activity and DNA repair

➡️ This combination makes HBOT particularly promising for use in cognitive impairments, long COVID, stroke, and brain aging processes

✨ Highlights & Callouts

"HBOT acts as a stimulus that initiates healing processes in the central nervous system—comparable to targeted training."

✅ Activates HIF-1α, VEGF, BDNF – key proteins for vascular growth & brain performance
✅ Increased neurogenesis in the hippocampus (memory center)
✅ Improved energy supply through mitochondrial optimization
✅ Reduction of neuroinflammatory processes

📌 Good to know

The concept of the hyperoxic-hypoxic paradox explains why alternating oxygen states trigger repair mechanisms – without real oxygen deficiency

The role of HBOT in neurodegenerative diseases such as Alzheimer’s is also discussed
The work makes it clear that HBOT is not merely a symptomatic therapy, but can have regenerative and preventive effects

"HBOT represents an evidence-based procedure with high therapeutic potential, particularly in cases of post-infectious and neurodegenerative conditions."

📈 Conclusion

This work is among the most comprehensive German publications on HBOT that connect science, medicine, and clinical practice. A must-read for anyone who wants to understand why HBOT works – and not just if.

What was observed?

Highlights and Points of Interest

Schön zu wissen

Conclusion

Study (PDF)