Authors: Shai Efrati et al.
Type of Study: Prospective, controlled study
Location: Sagol Center for Hyperbaric Medicine and Research, Israel
Publication: Aging (Albany NY), 2020
🔍What was observed?
This study shows for the first time that Hyperbaric Oxygen Therapy (HBOT) is capable of reversing key markers of aging:
Extending telomeres by up to 38%
Reduction of senescent (aged) immune cells by up to 37%
🧬 Telomeres are protective caps at the ends of chromosomes. They shorten with each cell cycle and are considered biological markers of cell age.
➡️ The participants underwent 60 HBOT sessions over 3 months. Blood analyses conducted before, during, and after the therapy revealed significant rejuvenation effects.
✨ Highlights & Key Points
"The telomere length of the T-helper cells (CD4+) increased by 38% – one of the highest changes ever documented."
✅ 60 sessions (5x/week, 90 min, 2 ATA)
✅ No medication – only oxygen and pressure
✅ Improved immune system function
✅ Reduction of senescent T-cells (CD28–) by 37%
✅ Verification through objective cell analysis (qPCR, immunoprofiles)
📌 Good to know
This study was a milestone in longevity research - cited worldwide by biohackers, doctors, and researchers.
It was published in the renowned journal "Aging" and received international attention.
The effect is based on the so-called Hyperoxic-Hypoxic Paradox: by alternating oxygen levels, repair genes are activated - similar to fasting or cold/heat therapy.
"For the first time, it has been demonstrated that a non-pharmacological intervention can significantly increase telomere length and reverse immunosenescence."
📈 Conclusion
This study provides the scientific evidence that HBOT can not only alleviate symptoms but also actively reverse cellular aging processes. A key contribution to modern longevity medicine and the biohacking scene.
Study (PDF)
Study (PDF)
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