Study Type: Prospective single-group study with pre-post design
Participants: 35 healthy adults (64+ years)
Location: Sagol Center for Hyperbaric Medicine and Research, Israel
🔍What has been observed?
This study examines whether Hyperbaric Oxygen Therapy (HBOT) alters the gene expression (transcriptome) in older adults – that is, which genes are active or inactive.
🧪 Result: After just 60 sessions over 3 months, measurable systemic changes in gene activity were observed.
➡️ The activated genes primarily affect:
Anti-inflammatory responses
Immune function
Cell cycle & repair
Longevity & stress resistance
✨ Highlights & Annotations
"HBOT induces gene expression patterns associated with longevity, cell regeneration, and anti-inflammation."
✅ Over 1,000 genes showed significant changes
✅ 811 genes upregulated, 222 downregulated
✅ Strongest effects in the immune system and inflammatory response
✅ Genes for DNA repair and cell protection were also activated
✅ Blood samples taken before and after therapy indicate a significant shift
📌 Good to know
This is one of the first studies to show the effect of a non-pharmacological therapy directly on the human transcriptome
Many of the activated genes overlap with known longevity and resilience pathways (e.g., FOXO, NRF2, HIF1a)
The study demonstrates that HBOT can "reprogram" the body to better handle aging processes and stressors
Our data demonstrate that HBOT modulates cellular processes that are closely linked to aging and functional regeneration.
📈 Conclusion
This study is a breakthrough in aging and cell research. It demonstrates that HBOT is capable of specifically influencing the gene activity of older individuals – with effects on immune response, cell protection, and longevity. This positions HBOT as a potent tool in epigenetics and longevity medicine.
Study (PDF)
Study (PDF)
Legal Notice Terms and Conditions About Us
X4 Innovation GmbH © 2025 All Rights Reserved
